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arrow_backExplore/Vitamin E
Tier-CPublic-ready6/25/2026

Vitamin E

Glucose and metabolic health markers is closer to a research marker, so it should be read separately from a directly felt benefit.

Human evidence exists, but it is mostly in patient or disease contexts, so the score is handled conservatively.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed
85
Caution signal
Low
Representative score
68.5
Glucose and metabolic health markersStress Response and Sleep ChangesCholesterol and triglycerides

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Glucose and metabolic health
5 studiesTier-B
Glucose and metabolic health markers
Fairly consistent positive signal in studiesResearch marker focusPatient-group study

This card is closer to a measured biomarker or lab outcome than a directly felt user benefit. These findings come from a defined study population, so everyday effects may differ.

Evidence score
56.7
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Stress and mood
4 studiesTier-B
Stress Response and Sleep Changes
Fairly consistent positive signal in studiesFelt benefit focusPatient-group study

These findings come from stress response, cortisol, anxiety, or sleep outcomes. They may mix felt benefits with physiological markers.

Evidence score
54.6
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Blood lipids
3 studiesTier-B
Cholesterol and triglycerides
Fairly consistent positive signal in studiesFelt benefit focusPatient-group study

Potential benefit studied in Blood lipids. These findings come from a defined study population, so everyday effects may differ.

Evidence score
52.0
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Women's health
2 studiesTier-C
Menstrual and women's health
Fairly consistent positive signal in studiesFelt benefit focusPatient-group study

Potential benefit studied in Women's health. These findings come from a defined study population, so everyday effects may differ.

Evidence score
48.7
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Immune and respiratory health
1 studiesTier-C
Immune and respiratory support
Some positive signal observedFelt benefit focusPatient-group study

Potential benefit studied in Immune and respiratory health. These findings come from a defined study population, so everyday effects may differ.

Evidence score
42.1
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Fatigue and energy
1 studiesTier-C
Fatigue and energy
Some positive signal observedFelt benefit focusPatient-group study

Potential benefit studied in Fatigue and energy. These findings come from a defined study population, so everyday effects may differ.

Evidence score
21.7
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Recent research

Updated This Month10 new papers

Study dosage range (reference only)

Lower dose
15
mg/day
Higher dose
15
mg/day
Dosages used in research papers, shown as reference context.
Not personal dosing instructions, recommendations, or safety limits.

Key cautions to review

Standalone side-effect signals and combination cautions are listed separately.

Caution index
0.8
Caution band: Low
Caution signals
3
Side effects + combos + curated rules
Key precautions
No curated contraindication rule is available yet, but literature caution signals are shown below.
2 combo signals and 0 added-signal combos shown below.
Standalone side effects, combination cautions, and positive combos are separated below.

Combination caution signals

! 와파린Vitamin E's anticoagulant effects amplify the risk of bleeding when combined with blood thinners.

Standalone side effects

Cancer1 papers
High-dose Vitamin E supplementation has been linked to adverse outcomes including certain cancers.human · systematic-review
Adverse effect signal1 papers
The review states that high-dose Vitamin E supplementation is linked to enhanced risks of all-cause mortality, hemorrhagic stroke, cardiovascular events, and certain cancers.human · unknown

Combinations studied together

The group showed a positive signal, but individual contributions are hard to isolate. Not a stack recommendation.

+비타민 CIn a triple-blind RCT of 60 women with endometriosis, a combination of Vitamin C (1000 mg/day) and Vitamin E (800 IU/day) for 8 weeks significantly reduced pelvic pain, dysmenorrhea, and dyspareunia compared to placebo (p < 0.001).
+SeleniumCombined supplementation with Selenium and Vitamin E demonstrated significant improvement in ovarian reserve markers compared to placebo.

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1
Public scholarly dataCitation signal: 651
review

An expanding body of evidence support that members of the vitamin E family are functionally unique, and title claims in manuscripts should be limited to the specific form of vitamin E studied.

Key Evidence #2
Public scholarly dataCitation signal: 575
review

The main focus of the review is on the tocopherol class of the vitamers, which helps to reduce the production of prostaglandins such as thromboxane, which cause platelet clumping.

Key Evidence #3
Public scholarly dataCitation signal: 481
review

The immunological changes observed with vitamin E intervention in animals and humans are summarized, and the cell-specific effects of vitamin E are described in order to understand the mechanisms of immunomodulation and implications ofitamin E for immunologica

3 more summariesLimited representative sample by study type.
>
Public scholarly dataCitation signal: 276
review

While both tocopherols exhibit anti-inflammatory activity in vitro and in vivo, supplementation with mixed (gammaT-enriched) tocopHerols seems to be more potent than supplementation with alphaT alone, which may explain the mostly negative outcomes of the recen

Public scholarly dataCitation signal: 257
observational

In this proof-of-concept study, combination therapy was better than placebo in improving liver histology in patients with NASH and T2DM and vitamin E alone did not significantly change the primary histological outcome.

Public scholarly dataCitation signal: 201
observational

It is shown that myocytes in intact muscle cannot repair membranes when exposed to an oxidant challenge, but show enhanced repair when supplemented with vitamin E, suggesting that this function is essential for maintenance of skeletal muscle homeostasis.

Vitamin E
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