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arrow_backExplore/Vitamin C
Tier-BPublic-ready6/25/2026

Vitamin C

Glucose and metabolic health markers is closer to a research marker, so it should be read separately from a directly felt benefit.

Human evidence exists, but it is mostly in patient or disease contexts, so the score is handled conservatively.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed
122
Caution signal
Low
Representative score
74.4
Glucose and metabolic health markersImmune and respiratory supportCholesterol and triglycerides

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Glucose and metabolic health
6 studiesTier-B
Glucose and metabolic health markers
Fairly consistent positive signal in studiesResearch marker focusPatient-group study

This card is closer to a measured biomarker or lab outcome than a directly felt user benefit. These findings come from a defined study population, so everyday effects may differ.

Evidence score
58.5
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Immune and respiratory health
4 studiesTier-B
Immune and respiratory support
Fairly consistent positive signal in studiesFelt benefit focusPatient-group study

Potential benefit studied in Immune and respiratory health. These findings come from a defined study population, so everyday effects may differ.

Evidence score
54.6
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Blood lipids
4 studiesTier-B
Cholesterol and triglycerides
Fairly consistent positive signal in studiesFelt benefit focusPatient-group study

Potential benefit studied in Blood lipids. These findings come from a defined study population, so everyday effects may differ.

Evidence score
54.6
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Bone and joint health
2 studiesTier-C
Bone, joint, and mobility
Fairly consistent positive signal in studiesFelt benefit focusPatient-group study

Potential benefit studied in Bone and joint health. These findings come from a defined study population, so everyday effects may differ.

Evidence score
48.7
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Stress and mood
2 studiesTier-C
Stress Response and Sleep Changes
Fairly consistent positive signal in studiesFelt benefit focusPatient-group study

These findings come from stress response, cortisol, anxiety, or sleep outcomes. They may mix felt benefits with physiological markers.

Evidence score
48.7
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Digestion and gut health
2 studiesTier-C
Digestion and gut comfort
Fairly consistent positive signal in studiesFelt benefit focusPatient-group study

Potential benefit studied in Digestion and gut health. These findings come from a defined study population, so everyday effects may differ.

Evidence score
48.7
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Recent research

Updated This Month10 new papers

Study dosage range (reference only)

Lower dose
1000
mg/day
Higher dose
1000
mg/day
Dosages used in research papers, shown as reference context.
Not personal dosing instructions, recommendations, or safety limits.

Key cautions to review

Standalone side-effect signals and combination cautions are listed separately.

Caution index
0.8
Caution band: Low
Caution signals
4
Side effects + combos + curated rules
Key precautions
No curated contraindication rule is available yet, but literature caution signals are shown below.
1 combo signals and 0 added-signal combos shown below.
Standalone side effects, combination cautions, and positive combos are separated below.

Standalone side effects

Oxalate renal stones1 papers
High doses of Vitamin C may cause overt side effects such as oxalate renal stones in susceptible patients.human · systematic-review
Adverse effect signal1 papers
The review mentions that administration of high doses of Vitamin C can cause overt side effects, specifically oxalate renal stones, in some susceptible patients.human · unknown
Adverse effect signal1 papers
High-dose and low-dose vitamin C supplementation has been reported to cause secondary calcium oxalate nephropathy, worsen acute kidney injury, and delay renal recovery in non-burn patients.human · unknown
Adverse effect signal1 papers
A case series identified calcium oxalate nephropathy in burn patients following high-dose vitamin C therapy.human · unknown

Combinations studied together

The group showed a positive signal, but individual contributions are hard to isolate. Not a stack recommendation.

+비타민 EIn a triple-blind RCT of 60 women with endometriosis, daily supplementation with 1000 mg Vitamin C and 800 IU Vitamin E for 8 weeks significantly reduced pelvic pain, dysmenorrhea, and dyspareunia compared to placebo.

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1
Public scholarly dataCitation signal: 448
review

The current evidence for the use of vitamin C and quercetin both for prophylaxis in high-risk populations and for the treatment of COVID-19 patients as an adjunct to promising pharmacological agents such as Remdesivir or convalescent plasma is presented.

Key Evidence #2
Public scholarly dataCitation signal: 421
review

Vitamin C is relatively safe, but caution should be given to the administration of high doses, which can cause overt side effects in some susceptible patients (e.g., oxalate renal stones), and analytical methods for its determination with advantages and pitfal

Key Evidence #3
Public scholarly dataCitation signal: 290
review

The L-enantiomer of ascorbic acid, commonly known as vitamin C, is an indispensable nutrient and plays a key role in retaining the physiological process of humans and animals and its interaction with coexisting components.

3 more summariesLimited representative sample by study type.
>
Public scholarly dataCitation signal: 256
review

In this review, the multiple roles of vitamin C in plant physiology as well as the regulation of its content, through biosynthetic or recycling pathways, are analyzed and attention is paid to the strategies that have been used to increase the content of vitami

Public scholarly dataCitation signal: 191
observational

Supplemental vitamin C to pregnant smokers improved newborn PFTs and decreased wheezing through 1 year in the offspring and may be an inexpensive and simple approach to decrease the effects of smoking in pregnancy on newborn pulmonary function and respiratory

Public scholarly dataCitation signal: 189
review

The available evidence indicates that vitamin C hypovitaminosis and deficiency is common in low- and middle-income countries and not uncommon in high income settings, and suggests a need for interventions to prevent deficiency in a range of at risk groups and

Vitamin C
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