Thiamine

Tier-BPublic-ready6/25/2026

Glucose and metabolic health markers is closer to a research marker, so it should be read separately from a directly felt benefit.

Some human supplement-context evidence is present and directly informs the score.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed

Caution signal

Low

Representative score

62.7

Glucose and metabolic health markersCholesterol and triglyceridesMenstrual and women's health

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Glucose and metabolic health

6 studiesTier-B

Glucose and metabolic health markers

Fairly consistent positive signal in studiesResearch marker focusPatient-group study

This card is closer to a measured biomarker or lab outcome than a directly felt user benefit. These findings come from a defined study population, so everyday effects may differ.

Evidence score

58.5

Study context

Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Blood lipids

2 studiesTier-C

Cholesterol and triglycerides

Fairly consistent positive signal in studiesFelt benefit focusPatient-group study

Potential benefit studied in Blood lipids. These findings come from a defined study population, so everyday effects may differ.

Evidence score

48.7

Study context

Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Women's health

1 studiesTier-C

Menstrual and women's health

Some positive signal observedFelt benefit focusPatient-group study

Potential benefit studied in Women's health. These findings come from a defined study population, so everyday effects may differ.

Evidence score

44.0

Study context

Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Digestion and gut health

1 studiesTier-C

Digestion and gut comfort

Some positive signal observedFelt benefit focusSupplement context

Potential benefit studied in Digestion and gut health.

Evidence score

44.0

Study context

Supplement context

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Cognition and focus

1 studiesTier-C

Cognition, memory, and focus

Some positive signal observedFelt benefit focusPatient-group study

Potential benefit studied in Cognition and focus. These findings come from a defined study population, so everyday effects may differ.

Evidence score

20.9

Study context

Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Recent research

Updated This Month10 new papers

Key cautions to review

Standalone side-effect signals and combination cautions are listed separately.

Caution index

0.6

Caution band: Low

Caution signals

Side effects + combos + curated rules

Key precautions

No combination caution signal is clear enough to show right now. This does not guarantee safety.

Standalone side effects, combination cautions, and positive combos are separated below.

Side-effect and combination signals

No standalone side-effect or combination signal is currently clear enough to show from the collected papers. This does not mean there is no concern.

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1

Public scholarly dataCitation signal: 413

review

Neurotropic B vitamins play crucial roles as coenzymes and beyond in the nervous system, but they can improve certain neurological conditions even without a (proven) deficiency.

Key Evidence #2

Public scholarly dataCitation signal: 185

review

It is shown that in preclinical models, reduced thiamine can drive AD‐like abnormalities, including memory deficits, neuritic plaques, and hyperphosphorylation of tau, and excessThiamine diminishesAD‐like pathologies.

Key Evidence #3

Public scholarly dataCitation signal: 143

observational

Current knowledge of the biological functions of thiamine, its antioxidant properties, and the effects of its deficiency in the body are presented.

3 more summariesLimited representative sample by study type.

Public scholarly dataCitation signal: 138

observational

The results demonstrate that the D. melanogaster microbiota functions to provision thiamine to its host in a low-thiamine environment, enough to allow the development of flies on aThiamine-free diet.

Public scholarly dataCitation signal: 108

review

A literature review of the current knowledge of the disease including related clinical phenotypes, treatment approaches, update of pathogenic variants, as well as in vitro and in vivo functional models that provide pathogenic evidence and propose mechanisms fo

Public scholarly dataCitation signal: 102

observational

This study demonstrates that high blood levels ofThiamine can be achieved rapidly with oral thiamine hydrochloride, and is absorbed by both an active and nonsaturable passive process.

Thiamine

Evidence score: 62.7|Caution index: 0.6

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