Stress and mood
Stress Response and Sleep Changes
Goal tierNot rated yet
No direct evidence for general supplement use is confirmed under the current standard.
Check this goal in more detailPublic-ready7/4/2026
SAMe
Papers analyzed
70
Stress Response and Sleep Changes
Main benefit evidence
Review human evidence by goal.
Side effects and combination findings in studies
Findings from studies of this ingredient alone are separated from findings involving another supplement or medication.
Caution signals
2
Side effects + combos + curated rules
Key precautions
No curated contraindication rule is available yet, but literature caution signals are shown below.
These are signals reported in studies. They do not predict what will happen to an individual.
Findings to review with care
Side effects reported for the ingredient alone are separated from findings involving another supplement or medication.
Side effects reported when this ingredient was used alone
Symptoms or adverse events reported in studies of this ingredient without another active ingredient.
Adverse effect signal1 papers
The review mentions a potential for mania in patients with bipolar disorder when using SAMe.Human studies · Study type not identifiedadverse effects1 papers
Studies reported only mild, transient or non-clinically relevant side effects with SAMe use.Human studies · Systematic review