Riboflavin

Tier-BPublic-ready6/25/2026

Blood-Level or Deficiency Marker is closer to a research marker, so it should be read separately from a directly felt benefit.

Human evidence exists, but it is mostly in patient or disease contexts, so the score is handled conservatively.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed

Caution signal

Low

Representative score

59.8

Blood-Level or Deficiency MarkerStress Response and Sleep ChangesDigestion and gut comfort

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Nutrient status and deficiency

7 studiesTier-B

Blood-Level or Deficiency Marker

Fairly consistent positive signal in studiesResearch marker focusPatient-group study

This is based on lab markers such as blood levels, deficiency correction, or absorption. Read it separately from directly felt outcomes.

Evidence score

60.0

Study context

Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Stress and mood

1 studiesTier-C

Stress Response and Sleep Changes

Some positive signal observedFelt benefit focusPatient-group study

These findings come from stress response, cortisol, anxiety, or sleep outcomes. They may mix felt benefits with physiological markers.

Evidence score

44.0

Study context

Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Digestion and gut health

1 studiesTier-C

Digestion and gut comfort

Some positive signal observedFelt benefit focusPatient-group study

Potential benefit studied in Digestion and gut health. These findings come from a defined study population, so everyday effects may differ.

Evidence score

32.9

Study context

Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Exercise performance and recovery

1 studiesTier-C

Exercise performance and recovery

Signal is still limitedFelt benefit focusPatient-group study

Potential benefit studied in Exercise performance and recovery. These findings come from a defined study population, so everyday effects may differ.

Evidence score

5.3

Study context

Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Recent research

Updated This Month10 new papers

Key cautions to review

Standalone side-effect signals and combination cautions are listed separately.

Caution index

0.6

Caution band: Low

Caution signals

Side effects + combos + curated rules

Key precautions

No curated contraindication rule is available yet, but literature caution signals are shown below.

1 combo signals and 0 added-signal combos shown below.

Standalone side effects, combination cautions, and positive combos are separated below.

Standalone side effects

Riboflavin deficiency-induced apoptosis1 papers

The review discusses how riboflavin deficiency leads to apoptosis through mechanisms including redox imbalance, mitochondrial dysfunction, endoplasmic reticulum stress, and lipotoxicity.human · systematic-review

Combinations studied together

The group showed a positive signal, but individual contributions are hard to isolate. Not a stack recommendation.

+마그네슘The combination supplement significantly reduced the burden of disease as measured by the HIT-6 questionnaire compared to placebo (p=0.01).

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1

Public scholarly dataCitation signal: 164

review

The crucial role of riboflavin for general human health, and the clear benefits of rib oflavin treatment in patients with inborn errors of metabolism are described.

Key Evidence #2

Public scholarly dataCitation signal: 156

observational

Treatment with a proprietary nutritional supplement containing magnesium, riboflavin and Q10 had an impact on migraine frequency which showed a trend towards statistical significance and Migraine symptoms and burden of disease were statistically significantly

Key Evidence #3

Public scholarly dataCitation signal: 144

observational

The results suggest a lower intake of calcium, vitamin D and dairy and a higher intake of fruit, vegetables, protein, phosphorus, selenium, thiamine, riboflavin and vitamin B12 than recommended.

3 more summariesLimited representative sample by study type.

Public scholarly dataCitation signal: 129

observational

This review focuses on the clinical and biochemical features associated with biallelic FLAD1 mutations leading to FAD synthase deficiency, the only known primary defect in flavocoenzyme synthesis, in addition to providing an overview of clinical disorders asso

Public scholarly dataCitation signal: 124

observational

The results reveal that the majority of pregnant women in these two counties of rural Shaanxi had low intakes of nutrients that are essential for pregnancy such as iron and folate.

Public scholarly dataCitation signal: 111

observational

A new MR1-restricted TCR is identified that senses cells infected with S. pyogenes, a bacteria unable to biosynthesize riboflavin, which suggests that TRAV12-2+ clone recognizes unique antigens.

Riboflavin

Evidence score: 59.8|Caution index: 0.6

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