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Bio-Analyst

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Tier-BPublic-ready7/5/2026

Rhodiola

Exercise performance and recovery is the main area connected here, and any felt benefit should be read together with the human evidence base.

Some human supplement-context evidence is present and directly informs the score.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed
92
Caution signal
Low
Representative score
80.9
Exercise performance and recoveryFatigue and energyStress Response and Sleep Changes

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Exercise performance and recovery
10 studiesTier-S
Exercise performance and recovery
Fairly consistent positive signal in studiesFelt benefit focusSupplement context

Potential benefit studied in Exercise performance and recovery.

Evidence score
85.0
Study context
Supplement context

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Fatigue and energy
4 studiesTier-B
Fatigue and energy
Fairly consistent positive signal in studiesFelt benefit focusSupplement context

Potential benefit studied in Fatigue and energy.

Evidence score
66.0
Study context
Supplement context

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Stress and mood
4 studiesTier-B
Stress Response and Sleep Changes
Fairly consistent positive signal in studiesFelt benefit focusSupplement context

These findings come from stress response, cortisol, anxiety, or sleep outcomes. They may mix felt benefits with physiological markers.

Evidence score
66.0
Study context
Supplement context

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Cognition and focus
5 studiesTier-B
Cognition, memory, and focus
Fairly consistent positive signal in studiesFelt benefit focusSupplement context

Potential benefit studied in Cognition and focus.

Evidence score
59.2
Study context
Supplement context

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Recent research

Updated This Month10 new papers

Observed range in repeated studies

This range includes studies in specific patient groups. It is not a general dose or recommendation.

Lower observed study value
200
mg/day
Higher observed study value
2000
mg/day
Only ranges repeated in human, oral, single-ingredient studies are shown.
Not personal dosing instructions, recommendations, or safety limits.

Side effects and combination findings in studies

Findings from studies of this ingredient alone are separated from findings involving another supplement or medication.

Caution index
0.8
Caution band: Low
Caution signals
4
Side effects + combos + curated rules
Key precautions
No curated contraindication rule is available yet, but literature caution signals are shown below.
1 combo signals and 0 added-signal combos shown below.
These are signals reported in studies. They do not predict what will happen to an individual.

Findings to review with care

Side effects reported for the ingredient alone are separated from findings involving another supplement or medication.

Side effects reported when this ingredient was used alone

Symptoms or adverse events reported in studies of this ingredient without another active ingredient.

Adverse effect signal1 papers
The review states that Rhodiola rosea extracts may influence the metabolism of other drugs by inhibiting cytochrome P450 enzymes (CYP2C9, CYP2D6, CYP3A4) and P-gp activity, increasing the risk of unwanted interactions.Human studies · Study type not identified
Adverse Events1 papers
Rhodiola rosea resulted in significantly fewer adverse events (30.0%) compared to sertraline (63.2%) with a p-value of 0.012, indicating better tolerability.Human studies · Randomized controlled trial

Caution signals when used with another supplement or medication

These studies reported a negative change, reduced absorption, or another caution when substances were used together. They do not predict an individual outcome.

SSRIsPotential risk of serotonin syndrome when combined with SSRIs.
Tricyclic antidepressantsPotential risk of serotonin syndrome when combined with tricyclic antidepressants.

Positive combinations studied

Positive combination findings are separated by how the study compared the groups. This is not a recommendation to combine them.

Positive findings when used together

The combination had a positive result, but the contribution of each ingredient could not be separated.

CaffeineA randomized, double-blind, placebo-controlled trial in 48 male volleyball players found that combined Rhodiola rosea and caffeine supplementation significantly improved jump height, reduced power decline during high-frequency jumps, and lowered perceived exertion compared to placebo and single-agent groups.

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1
Public scholarly dataCitation signal: 251
rct

[Abstract]: The objective was to investigate the stimulating and normalizing effect of the adaptogen Rhodiola rosea extract SHR-5 in foreign students during a stressful examination period. The study was performed as a double-blind, randomized and placebo-contr

Key Evidence #2
Public scholarly dataCitation signal: 220
rct

[Abstract]: The objective of this study was to assess the efficacy and safety of standardized extract SHR-5 of rhizomes of Rhodiola rosea L. in patients suffering from a current episode of mild/moderate depression. The phase III clinical trial was carried out

Key Evidence #3
Public scholarly dataCitation signal: 215
rct

[Abstract]: The aim of the study was to assess the efficacy of the standardised extract SHR-5 of roots of Rhodiola Rosea L. in the treatment of individuals suffering from stress-related fatigue. The phase III clinical trial took the form of a randomised, doubl

3 more summariesLimited representative sample by study type.
>
Public scholarly dataCitation signal: 204
rct

[Abstract]: A randomized, double-blind, placebo-controlled, parallel-group clinical study with an extra non-treatment group was performed to measure the effect of a single dose of standardized SHR-5 Rhodiola rosea extract on capacity for mental work against a

Public scholarly dataCitation signal: 189
review

This paper will provide the theoretical basis for its clinical application, and provide the evidences or guidance for future studies and medicinal exploitations of Rhodiola rosea L.

Public scholarly dataCitation signal: 171
review

This review article summarizes the bioactivities, including adaptogenic, antifatigue, antidepressant, antioxidant, anti-inflammatory, antinoception, and anticancer activities, and the modulation of immune function of Rhodiola plants and its two constituents, a

Rhodiola
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