Cognition, memory, and focus is the main area connected here, and any felt benefit should be read together with the human evidence base.
Some human supplement-context evidence is present and directly informs the score.
Representative tier calculated from paper evidence that passed the collection audit.
The representative ingredient tier is calculated from these target-level evidence groups.
10 new papers were added in this period. No new risk signal was identified.
Standalone side-effect signals and combination cautions are listed separately.
No standalone side-effect or combination signal is currently clear enough to show from the collected papers. This does not mean there is no concern.
Paper IDs and full lists are private. Only study types and summaries are shown.
The biology of phosphatidylserine is discussed with respect to its role as a global immunosuppressive signal and how PS is exploited to drive diverse pathological processes such as infection and cancer.
It is shown that exposed phosphatidylserine (PS) represents a neuronal ‘eat-me’ signal enabling microglial-mediated synapse pruning and a novel role of developmentally regulated PS exposure that is common among developing brain structures is identified.
It is demonstrated that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease and binds phosphatidylserine (PS) and can specifically extract PS into membrane domains, favoring PS transfer to mitochondria and mitochondrialosphatidylethanol
ATG8-PS lipidation provides a specific ‘molecular signature’ for non-canonical autophagy, uncovering a novel means of detecting and monitoring this emerging pathway.
The fusion protein (FP) consisting of L-methionase linked to human Annexin-V has been reported to target the cancer cells, and prevents the methionine (essential amino acid) supplementation to thecancer cells.
It is suggested that a complete understanding of how regulated cell death processes affect the immune system is far from being fully elucidated.