Increased risks of death and hospitalization were observed in patients with idiopathic pulmonary fibrosis who were treated with a combination of prednisone, azathioprine, and NAC, as compared with placebo, providing evidence against the use of this combination
NAC
Exercise performance and recovery is the main area connected here, and any felt benefit should be read together with the human evidence base.
Some human supplement-context evidence is present and directly informs the score.
Representative tier calculated from paper evidence that passed the collection audit.
Main benefit evidence
The representative ingredient tier is calculated from these target-level evidence groups.
Exercise performance and recovery1 studiesTier-CExercise performance and recoverySome positive signal observedFelt benefit focusSupplement contextPotential benefit studied in Exercise performance and recovery.Open metrics>
Recent research
10 new papers were added in this period. No new risk signal was identified.
What's new
Most notable recent finding
Key cautions to review
Standalone side-effect signals and combination cautions are listed separately.
Standalone side effects
Evidence summaries
Paper IDs and full lists are private. Only study types and summaries are shown.
The purpose of this chapter is to provide an overview of the medicinal effects and applications of NAC to human health based on current therapeutic evidence.
The validity of conventional assumptions and the scope of a newly discovered mechanism of action, namely the conversion of NAC into hydrogen sulfide and sulfane sulfur species, are discussed.
3 more summariesLimited representative sample by study type.>
An overview of the most relevant and recent evidence on the clinical application of NAC is provided, with a focus on respiratory diseases, acetaminophen poisoning, disorders of the central nervous system, cardiovascular disease, contrast-induced nephropathy, a
The efficacy and mechanism of action of NAC is examined in rodent models of hemorrhagic stroke and it is shown that NAC acts as a “redox modulatory” agent in these models.
The purpose of this paper is to give an overview on the effects and applications of NAC in Parkinson's and Alzheimer's disorders and in neuropathic pain and stroke.