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Public-ready7/5/2026

Melatonin

Papers analyzed
120
Stress Response and Sleep ChangesGlucose and metabolic health markersBlood pressure and vascular health markers

Main benefit evidence

Review human evidence by goal.

Sleep
Stress Response and Sleep Changes
Goal tierNot rated yet

Direct evidence for general supplement use is currently limited under this standard.

8 human studies in a specific clinical context are available separately.

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Glucose and metabolic health
Glucose and metabolic health markers
Goal tierNot rated yet

Direct evidence for general supplement use is currently limited under this standard.

2 human studies in a specific clinical context are available separately.

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Blood pressure and vascular health
Blood pressure and vascular health markers
Goal tierNot rated yet

Direct evidence for general supplement use is currently limited under this standard.

1 human studies in a specific clinical context are available separately.

Check this goal in more detail
Blood lipids
Cholesterol and triglycerides
Goal tierNot rated yet

No direct evidence for general supplement use is confirmed under the current standard.

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Pain and headache
Pain, headache, and migraine
Goal tierNot rated yet

The currently linked research coverage is not broad enough to characterize this goal yet.

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Side effects and combination findings in studies

Findings from studies of this ingredient alone are separated from findings involving another supplement or medication.

Caution signals
1
Side effects + combos + curated rules
Key precautions
No curated contraindication rule is available yet, but literature caution signals are shown below.
1 combo signals and 0 added-signal combos shown below.
These are signals reported in studies. They do not predict what will happen to an individual.

Findings to review with care

Side effects reported for the ingredient alone are separated from findings involving another supplement or medication.

Side effects reported when this ingredient was used alone

Symptoms or adverse events reported in studies of this ingredient without another active ingredient.

Adverse events1 papers
Melatonin was well tolerated with minimal side effects (n=10).Human studies · Randomized controlled trial

Positive combinations studied

Positive combination findings are separated by how the study compared the groups. This is not a recommendation to combine them.

Positive findings when used together

The combination had a positive result, but the contribution of each ingredient could not be separated.

마그네슘Combined melatonin and magnesium supplementation was more effective in improving serum levels of insulin compared to baseline.