Manganese

Tier-CPublic-ready6/26/2026

Glucose and metabolic health markers is closer to a research marker, so it should be read separately from a directly felt benefit.

Human evidence exists, but it is mostly in patient or disease contexts, so the score is handled conservatively.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed

Caution signal

Moderate

Representative score

45.1

Glucose and metabolic health markersDigestion and gut comfort

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Glucose and metabolic health

3 studiesTier-B

Glucose and metabolic health markers

Fairly consistent positive signal in studiesResearch marker focusPatient-group study

This card is closer to a measured biomarker or lab outcome than a directly felt user benefit. These findings come from a defined study population, so everyday effects may differ.

Evidence score

52.0

Study context

Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Digestion and gut health

1 studiesTier-C

Digestion and gut comfort

Some positive signal observedFelt benefit focusPatient-group study

Potential benefit studied in Digestion and gut health. These findings come from a defined study population, so everyday effects may differ.

Evidence score

44.0

Study context

Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Recent research

Updated This Month10 new papers

Key cautions to review

Standalone side-effect signals and combination cautions are listed separately.

Caution index

2.5

Caution band: Moderate

Caution signals

Side effects + combos + curated rules

Key precautions

No curated contraindication rule is available yet, but literature caution signals are shown below.

Standalone side effects, combination cautions, and positive combos are separated below.

Standalone side effects

Endocrine disruption1 papers

The review evaluates manganese as an endocrine-disrupting chemical with potential toxicity on animals and humans, though specific mechanisms remain unclear.human · systematic-review

Developmental Neurotoxicity1 papers

Manganese is identified as an additional developmental neurotoxicant based on epidemiological studies documenting its association with neurodevelopmental disabilities.human · systematic-review

Brain function1 papers

The review states that while manganese is an essential element, higher amounts may be toxic, primarily affecting the brain.human · systematic-review

oxidative stress1 papers

The review highlights evidence implicating oxidative stress in the pathogenesis of manganese neurotoxicity.human · unknown

neuropsychological performance1 papers

A meta-analysis of occupationally exposed workers found significantly slowed motor performance and deficits in attention and short-term memory associated with manganese exposure.human · meta-analysis

manganese-induced neurotoxicity1 papers

Systematic review found insufficient data to establish a tolerable upper intake level for manganese due to lack of dose-response evidence but set a safe intake level of 8 mg/day for adults based on neurotoxicity risk from human and animal studies.human · systematic-review

Intestinal lipid deposition1 papers

High dietary manganese exposure in yellow catfish induces intestinal lipid accumulation by activating the oxidative stress–SIRT1–PPARγ axis.animal · animal-study

Intelligence Quotient (IQ)1 papers

Higher manganese exposure is adversely associated with childhood neurodevelopment, specifically showing a negative correlation between hair manganese levels and Full Scale IQ in children aged 6–18 years.human · meta-analysis

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1

Public scholarly dataCitation signal: 1581

review

To control the pandemic of developmental neurotoxicity, a global prevention strategy is proposed and chemicals in existing use and all new chemicals must therefore be tested for developmental neurotoxicity is proposed.

Key Evidence #2

Public scholarly dataCitation signal: 934

review

Average blood levels of biologically important trace elements were substantially different in hemodialysis patients, compared with healthy controls.

Key Evidence #3

Public scholarly dataCitation signal: 716

review

This report provides a comprehensive review on new knowledge gained in the Mn research field and suggests that beyond traditionally recognized occupational manganism, Mn exposures and the ensuing toxicities occur in a variety of environmental settings, nutriti

3 more summariesLimited representative sample by study type.

Public scholarly dataCitation signal: 185

review

The current knowledge of the MnSOD enzymatic mechanism and ongoing studies into solving the remaining mysteries are reviewed, focusing on human MnS OD, the most significant enzyme in protecting against ROS in the human body.

Public scholarly dataCitation signal: 179

observational

The emerging evidence suggests that working memory is significantly affected by chronic Mn exposure and this may be mediated by alterations in brain structures associated with the working memory network including the caudate nucleus in the striatum, frontal co

Public scholarly dataCitation signal: 163

review

This review provides a comprehensive assessment of the main implications and challenges of Mn treatment in mine drainage and highlights both their design criteria and operation requirements, as well as the factors that influence Mn removal efficiency.

Manganese

Evidence score: 45.1|Caution index: 2.5

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