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arrow_backExplore/Magnesium
Tier-BPublic-ready6/25/2026

Magnesium

Glucose and metabolic health markers is closer to a research marker, so it should be read separately from a directly felt benefit.

Human evidence exists, but it is mostly in patient or disease contexts, so the score is handled conservatively.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed
50
Caution signal
Low
Representative score
69.2
Glucose and metabolic health markersStress Response and Sleep ChangesDigestion and gut comfort

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Glucose and metabolic health
9 studiesTier-B
Glucose and metabolic health markers
Fairly consistent positive signal in studiesResearch marker focusPatient-group study

This card is closer to a measured biomarker or lab outcome than a directly felt user benefit. These findings come from a defined study population, so everyday effects may differ.

Evidence score
62.6
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Stress and mood
5 studiesTier-B
Stress Response and Sleep Changes
Fairly consistent positive signal in studiesFelt benefit focusPatient-group study

These findings come from stress response, cortisol, anxiety, or sleep outcomes. They may mix felt benefits with physiological markers.

Evidence score
56.7
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Digestion and gut health
2 studiesTier-C
Digestion and gut comfort
Fairly consistent positive signal in studiesFelt benefit focusPatient-group study

Potential benefit studied in Digestion and gut health. These findings come from a defined study population, so everyday effects may differ.

Evidence score
48.7
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Blood lipids
2 studiesTier-C
Cholesterol and triglycerides
Fairly consistent positive signal in studiesFelt benefit focusPatient-group study

Potential benefit studied in Blood lipids. These findings come from a defined study population, so everyday effects may differ.

Evidence score
48.7
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Nutrient status and deficiency
1 studiesTier-C
Blood-Level or Deficiency Marker
Some positive signal observedResearch marker focusPatient-group study

This is based on lab markers such as blood levels, deficiency correction, or absorption. Read it separately from directly felt outcomes.

Evidence score
44.0
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Recent research

Updated This Month10 new papers

Study dosage range (reference only)

Lower dose
300
mg/day
Higher dose
300
mg/day
Dosages used in research papers, shown as reference context.
Not personal dosing instructions, recommendations, or safety limits.

Key cautions to review

Standalone side-effect signals and combination cautions are listed separately.

Caution index
0.8
Caution band: Low
Caution signals
1
Side effects + combos + curated rules
Key precautions
No curated contraindication rule is available yet, but literature caution signals are shown below.
3 combo signals and 0 added-signal combos shown below.
Standalone side effects, combination cautions, and positive combos are separated below.

Standalone side effects

Treatment-related adverse events1 papers
17.4% of subjects treated with magnesium alone experienced adverse events potentially related to treatment.human · rct

Combinations studied together

The group showed a positive signal, but individual contributions are hard to isolate. Not a stack recommendation.

+비타민 B6In subjects with severe/extremely severe stress, the combination of magnesium and vitamin B6 resulted in a 24% greater improvement compared to magnesium alone (p=0.0203).
+비타민 DCo-supplementation with Vitamin D and Magnesium resulted in significant improvements in behavioral function and mental health scores compared to placebo.
+MelatoninCo-supplementation with magnesium and melatonin resulted in a significant greater decrease in testosterone concentrations compared with placebo and improved metabolic profiles including insulin, HOMA-IR, and cholesterol levels.

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1
Public scholarly dataCitation signal: 219
meta-analysis

Increasing dietary magnesium intake is associated with a reduced risk of stroke, heart failure, diabetes, and all-cause mortality, but not CHD or total CVD, which supports the notion that increasing dietary magnesium might provide health benefits.

Key Evidence #2
Public scholarly dataCitation signal: 152
observational

[Abstract]: Background: Nearly 50% of older adults have insomnia, with difficulty in getting to sleep, early awakening, or feeling unrefreshed on waking. With aging, several changes occur that can place one at risk for insomnia, including age-related changes i

Key Evidence #3
Public scholarly dataCitation signal: 150
review

Existing evidence is suggestive of a beneficial effect of Mg on subjective anxiety in anxiety vulnerable samples, however, the quality of the existing evidence is poor.

3 more summariesLimited representative sample by study type.
>
Public scholarly dataCitation signal: 148
observational

Data suggest that VitK2 supplementation might improve bone quality and reduce fracture risk in osteoporotic patients, potentially enhancing the efficacy of Ca ± vitD and Mg supplementation, but data regarding the effectiveness of vitK2 and MG supplementation o

Public scholarly dataCitation signal: 140
review

From the available evidence, it emerged that supplementation with magnesium could be beneficial, however, the results are not univocal, both in terms of the plasma levels and of therapeutic effects.

Public scholarly dataCitation signal: 129
observational

MgO, but not AST-120, appears to be effective in slowing CAC progression in CKD, and larger-scale trials are warranted to confirm these findings.

Magnesium
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