biotech

Bio-Analyst

Research Platform
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Tier-BPublic-ready6/20/2026

L-Theanine

Stress Response and Sleep Changes is the main area connected here, and any felt benefit should be read together with the human evidence base.

Some human supplement-context evidence is present and directly informs the score.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed
47
Caution signal
Low
Representative score
66.8
Stress Response and Sleep ChangesCognition, memory, and focus

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Stress and mood
4 studiesTier-B
Stress Response and Sleep Changes
Fairly consistent positive signal in studiesFelt benefit focusSupplement context
These findings come from stress response, cortisol, anxiety, or sleep outcomes. They may mix felt benefits with physiological markers.
Open metrics
>
Stress and mood balanceSleep quality
No direct rate reported. Read direction and evidence strength together.
Evidence score
66.0
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Cognition and focus
2 studiesTier-C
Cognition, memory, and focus
Fairly consistent positive signal in studiesFelt benefit focusSupplement context
Potential benefit studied in Cognition and focus.
Open metrics
>
Cognition, memory, and focus
No direct rate reported. Read direction and evidence strength together.
Evidence score
46.6
Score reflects signal strength. Tier also considers paper count, repetition, and study context.

Recent research

Updated This Month10 new papers

10 new papers were added in this period. No new risk signal was identified.

What's new

10 new papers were added.No new risk signal was identified.

Most notable recent finding

This is the most meaningful new study in the latest update.
review
Why it mattersIt ranked highest among the newly collected papers for this ingredient in the latest update.
View paper

Study dosage range (reference only)

Lower dose
200
mg/day
Higher dose
400
mg/day
Dosages used in research papers, shown as reference context.
Not personal dosing instructions, recommendations, or safety limits.

Key cautions to review

Standalone side-effect signals and combination cautions are listed separately.

Caution index
0.6
Caution band: Low
Caution signals
0
Side effects + combos + curated rules
Key precautions
No combination caution signal is clear enough to show right now. This does not guarantee safety.
1 combo signals and 0 added-signal combos shown below.
Standalone side effects, combination cautions, and positive combos are separated below.

Combinations studied together

The group showed a positive signal, but individual contributions are hard to isolate. Not a stack recommendation.

+CaffeineCombined intake of L-theanine and caffeine demonstrated superior improvement in shooting scores and cognitive reaction times compared to either supplement alone or placebo.

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1
Public scholarly dataCitation signal: 79
review

Theanine administration elicits selective changes in alpha brain wave activity with concomitant increases in selective attention during the execution of mental tasks, and elicits improvements in cognitive function including learning and memory in human and ani

Key Evidence #2
Public scholarly dataCitation signal: 131
observational

It is suggested that L-theanine has the potential to promote mental health in the general population with stress-related ailments and cognitive impairments.

Key Evidence #3
Public scholarly dataCitation signal: 100
observational

It is shown that L-theanine not only reduces anxiety but also attenuates the blood-pressure increase in high-stress-response adults.

3 more summariesLimited representative sample by study type.
>
Public scholarly dataCitation signal: 85
observational

Combining L-theanine with caffeine, at levels and ratios equivalent to one to two cups of tea, eliminated the vasoconstrictive effect and behavioural effects of caffeine and supports previous findings of an interaction between these substances, despite a lack

Public scholarly dataCitation signal: 71
observational

It is demonstrated that L-theanine inhibits intestinal inflammation and protects against intestinal barrier disruption in mice with DSS-induced colitis.

Public scholarly dataCitation signal: 65
review

Considering the anti‐inflammatory and antioxidants effects of l‐THE presented in the current review, further research must translate the existing knowledge gained from animal and cell models to exploring the potential metabolic health benefits and moderating e

L-Theanine
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