biotech

Bio-Analyst

Research Platform
person
Tier-BPublic-ready6/25/2026

Folate

Menstrual and women's health is the main area connected here, and any felt benefit should be read together with the human evidence base.

Human evidence exists, but it is mostly in patient or disease contexts, so the score is handled conservatively.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed
85
Caution signal
Low
Representative score
61.8
Menstrual and women's healthBlood-Level or Deficiency MarkerStress Response and Sleep Changes

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Women's health
9 studiesTier-B
Menstrual and women's health
Fairly consistent positive signal in studiesFelt benefit focusPatient-group study

Potential benefit studied in Women's health. These findings come from a defined study population, so everyday effects may differ.

Evidence score
62.6
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Nutrient status and deficiency
3 studiesTier-B
Blood-Level or Deficiency Marker
Fairly consistent positive signal in studiesResearch marker focusPatient-group study

This is based on lab markers such as blood levels, deficiency correction, or absorption. Read it separately from directly felt outcomes.

Evidence score
52.0
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Stress and mood
3 studiesTier-B
Stress Response and Sleep Changes
Fairly consistent positive signal in studiesFelt benefit focusPatient-group study

These findings come from stress response, cortisol, anxiety, or sleep outcomes. They may mix felt benefits with physiological markers.

Evidence score
51.0
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Recent research

Updated This Month10 new papers

Study dosage range (reference only)

Lower dose
0.4
mg/day
Higher dose
0.8
mg/day
Dosages used in research papers, shown as reference context.
Not personal dosing instructions, recommendations, or safety limits.

Key cautions to review

Standalone side-effect signals and combination cautions are listed separately.

Caution index
1.0
Caution band: Low
Caution signals
1
Side effects + combos + curated rules
Key precautions
No curated contraindication rule is available yet, but literature caution signals are shown below.
1 combo signals and 0 added-signal combos shown below.
Standalone side effects, combination cautions, and positive combos are separated below.

Standalone side effects

Adverse effect signal1 papers
The review mentions possible side effects of folate supplementation in patients with Sickle Cell Disease, noting that the positive role is not well supported.human · unknown

Combinations studied together

The group showed a positive signal, but individual contributions are hard to isolate. Not a stack recommendation.

+Vitamin B12A randomized, single-blind, placebo-controlled trial of 101 Alzheimer's disease patients found that combined folic acid (1.2 mg/day) and vitamin B12 supplementation significantly improved cognitive performance scores and reduced inflammatory markers compared to placebo.

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1
Public scholarly dataCitation signal: 659
review

The results of the first comparison, involving 6708 births with information on NTDs and other infant outcomes, show a protective effect of daily folic acid supplementation (alone or in combination with other vitamins and minerals) in preventing N TDs compared

Key Evidence #2
Public scholarly dataCitation signal: 218
review

It is indicated that nationally representative data are needed to guide the development of nutrition interventions and public health programs, such as dietary diversification, micronutrient fortification and supplementation.

Key Evidence #3
Public scholarly dataCitation signal: 169
review

Folic acid's putative role in influencing the acquisition of epigenetic marks in the germline, acquired during embryogenesis, is discussed, as well as the role of FA in the management of cancerous disease.

3 more summariesLimited representative sample by study type.
>
Public scholarly dataCitation signal: 137
observational

Folate status data for WRA globally are limited and must be carefully interpreted due to methodological issues, and future surveys would benefit from using the microbiologic assay to assess folate status, along with assay‐matched cutoffs to improve monitoring

Public scholarly dataCitation signal: 122
observational

The human gut appears to have a very efficient capacity to convert reduced dietary folates to 5-MTHF but limited ability to reduce folic acid, which would suggest that humans are reliant on the liver for folic Acid reduction even though it has a low and highly

Public scholarly dataCitation signal: 118
observational

GOFA-DOX/HACPN could be deemed as a safe and efficient intratumoral drug delivery system for breast cancer therapy because of its anti-tumor efficacy and the targeting effect of FA, which resulted in enhanced in vitro cytotoxicity.

Folate
arrow_backBack to list