biotech

Bio-Analyst

Research Platform
person
Tier-BPublic-ready6/18/2026

Creatine

Exercise performance and recovery is the main area connected here, and any felt benefit should be read together with the human evidence base.

Some human supplement-context evidence is present and directly informs the score.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed
61
Caution signal
Low
Representative score
80.4
Exercise performance and recoveryCognition, memory, and focusFatigue and energy

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Exercise performance and recovery
9 studiesTier-A
Exercise performance and recovery
Fairly consistent positive signal in studiesFelt benefit focusSupplement context
Potential benefit studied in Exercise performance and recovery.
Open metrics
>
Exercise performance and recovery
No direct rate reported. Read direction and evidence strength together.
Evidence score
78.0
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Cognition and focus
3 studiesTier-B
Cognition, memory, and focus
Fairly consistent positive signal in studiesFelt benefit focusSupplement context
Potential benefit studied in Cognition and focus.
Open metrics
>
Cognition, memory, and focus
No direct rate reported. Read direction and evidence strength together.
Evidence score
66.0
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Fatigue and energy
2 studiesTier-C
Fatigue and energy
Some positive signal observedFelt benefit focusSupplement context
Potential benefit studied in Fatigue and energy.
Open metrics
>
Fatigue and energy
No direct rate reported. Read direction and evidence strength together.
Evidence score
27.1
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Bone and joint health
1 studiesTier-C
Bone, joint, and mobility
Some positive signal observedFelt benefit focusSupplement context
Potential benefit studied in Bone and joint health.
Open metrics
>
Bone, joint, and mobility
No direct rate reported. Read direction and evidence strength together.
Evidence score
20.9
Score reflects signal strength. Tier also considers paper count, repetition, and study context.

Recent research

Updated This Month10 new papers

10 new papers were added in this period. No new risk signal was identified.

What's new

10 new papers were added.No new risk signal was identified.

Most notable recent finding

This is the most meaningful new study in the latest update.
review
Why it mattersIt ranked highest among the newly collected papers for this ingredient in the latest update.
View paper

Study dosage range (reference only)

Lower dose
1.5
g/day
Higher dose
20
g/day
Dosages used in research papers, shown as reference context.
Not personal dosing instructions, recommendations, or safety limits.

Key cautions to review

Standalone side-effect signals and combination cautions are listed separately.

Caution index
0.9
Caution band: Low
Caution signals
2
Side effects + combos + curated rules
Key precautions
No combination caution signal is clear enough to show right now. This does not guarantee safety.
Standalone side effects, combination cautions, and positive combos are separated below.

Standalone side effects

Adverse effect signal1 papers
A case report described acute renal failure and acute tubular necrosis in an 18-year-old man taking creatine monohydrate, with full recovery observed after stopping the supplement.human · unknown
Side effects associated with use1 papers
The review covers side effects associated with creatine use but does not specify the nature or severity of these effects in the provided text.human · systematic-review

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1
Public scholarly dataCitation signal: 334
review

This review covers the basics of creatine synthesis and transport, proposed mechanisms of action, pharmacokinetics of exogenous creatine administration, creatine use in disease models, side effects associated with use, and issues on product quality.

Key Evidence #2
Public scholarly dataCitation signal: 699
review

An update to the current literature regarding the role and safety of creatine supplementation in exercise, sport, and medicine is provided and the position stand of International Society of Sports Nutrition (ISSN) is updated.

Key Evidence #3
Public scholarly dataCitation signal: 189
review

It is shown that creatine supplementation increases lean tissue mass and upper and lower body muscular strength during resistance training of older adults, but potential mechanisms by which creatine exerts these positive effects have yet to be evaluated extens

3 more summariesLimited representative sample by study type.
>
Public scholarly dataCitation signal: 178
review

An internationally renowned team of research experts was formed to perform an evidence-based scientific evaluation of the literature regarding creatine supplementation, which shows that creatine supplementation is relatively well tolerated, especially at recom

Public scholarly dataCitation signal: 151
observational

Data confirms that supervised resistance exercise training is safe and effective for increasing strength in older adults and that a combination of CrM and CLA can enhance some of the beneficial effects of training over a six-month period.

Public scholarly dataCitation signal: 137
observational

It is shown that creatine uptake is required to sustain this thermogenic pathway in adipocytes, and enhancing creatine uptake into adipocytes may offer an opportunity to combat obesity and obesity-associated metabolic dysfunction.

Creatine
arrow_backBack to list