biotech

Bio-Analyst

Research Platform
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Tier-BPublic-ready6/25/2026

Calcium

Menstrual and women's health is the main area connected here, and any felt benefit should be read together with the human evidence base.

Human evidence exists, but it is mostly in patient or disease contexts, so the score is handled conservatively.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed
51
Caution signal
Low
Representative score
59.8
Menstrual and women's healthGlucose and metabolic health markersBone, joint, and mobility

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Women's health
2 studiesTier-C
Menstrual and women's health
Fairly consistent positive signal in studiesFelt benefit focusPatient-group study

Potential benefit studied in Women's health. These findings come from a defined study population, so everyday effects may differ.

Evidence score
48.7
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Glucose and metabolic health
1 studiesTier-C
Glucose and metabolic health markers
Some positive signal observedResearch marker focusPatient-group study

This card is closer to a measured biomarker or lab outcome than a directly felt user benefit. These findings come from a defined study population, so everyday effects may differ.

Evidence score
44.0
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Bone and joint health
6 studiesTier-C
Bone, joint, and mobility
Some positive signal observedFelt benefit focusPatient-group study

Potential benefit studied in Bone and joint health. These findings come from a defined study population, so everyday effects may differ.

Evidence score
31.9
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Recent research

Updated This Month10 new papers

Key cautions to review

Standalone side-effect signals and combination cautions are listed separately.

Caution index
1.5
Caution band: Low
Caution signals
3
Side effects + combos + curated rules
Key precautions
No curated contraindication rule is available yet, but literature caution signals are shown below.
Standalone side effects, combination cautions, and positive combos are separated below.

Standalone side effects

renal stones1 papers
Side effects of calcium supplementation include renal stones.human · systematic-review
gastrointestinal symptoms1 papers
Side effects of calcium supplementation include gastrointestinal symptoms.human · systematic-review
Constipation1 papers
Calcium supplements cause gastrointestinal side effects, particularly constipation.human · rct

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1
Public scholarly dataCitation signal: 694
observational

The Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease study demonstrated safety and suggested benefit of adeno-associated virus type 1/sarcoplasmic reticulum Ca2+-ATPase in advanced heart failure, supporting larger confirma

Key Evidence #2
Public scholarly dataCitation signal: 547
meta-analysis

This meta-analysis of RCTs supports the use of calcium plus vitamin D supplements as an intervention for fracture risk reduction in both community-dwelling and institutionalized middle-aged to older adults.

Key Evidence #3
Public scholarly dataCitation signal: 343
review

An interactive global map is developed, categorizing countries based on average calcium intake and summarized differences in intake based on sex, age, and socioeconomic status, revealing that many countries have low average calcium Intake.

3 more summariesLimited representative sample by study type.
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Public scholarly dataCitation signal: 273
observational

In postmenopausal women, calcium plus vitamin D3 supplementation did not reduce either blood pressure or the risk of developing hypertension over 7 years of follow-up.

Public scholarly dataCitation signal: 233
observational

It is confirmed that, the positive responses in salt-stressed rice seedlings to exogenous Ca were for Ca mediated improvement of ion homeostasis, antioxidant defense and glyoxalase system.

Public scholarly dataCitation signal: 229
observational

The USPSTF concludes that the current evidence is insufficient to assess the balance of the benefits and harms of combined vitamin D and calcium supplementation for the primary prevention of fractures in premenopausal women or in men.

Calcium
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