biotech

Bio-Analyst

Research Platform
person
arrow_backExplore/Ashwagandha
Tier-BPublic-ready6/20/2026

Ashwagandha

Stress Response and Sleep Changes is the main area connected here, and any felt benefit should be read together with the human evidence base.

Some human supplement-context evidence is present and directly informs the score.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed
56
Caution signal
Low
Representative score
82.0
Stress Response and Sleep ChangesGlucose and metabolic health markersExercise performance and recovery

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Stress and mood
7 studiesTier-A
Stress Response and Sleep Changes
Fairly consistent positive signal in studiesFelt benefit focusSupplement context
These findings come from stress response, cortisol, anxiety, or sleep outcomes. They may mix felt benefits with physiological markers.
Open metrics
>
Stress and mood balanceSleep quality
No direct rate reported. Read direction and evidence strength together.
Evidence score
78.0
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Glucose and metabolic health
4 studiesTier-B
Glucose and metabolic health markers
Fairly consistent positive signal in studiesResearch marker focusSupplement context
This card is closer to a measured biomarker or lab outcome than a directly felt user benefit.
Closer to a research marker than a directly felt benefit.
Open metrics
>
Glucose and metabolic markers
No direct rate reported. Read direction and evidence strength together.
Evidence score
66.0
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Exercise performance and recovery
3 studiesTier-B
Exercise performance and recovery
Fairly consistent positive signal in studiesFelt benefit focusSupplement context
Potential benefit studied in Exercise performance and recovery.
Open metrics
>
Exercise performance and recovery
No direct rate reported. Read direction and evidence strength together.
Evidence score
66.0
Score reflects signal strength. Tier also considers paper count, repetition, and study context.
Cognition and focus
2 studiesTier-B
Cognition, memory, and focus
Fairly consistent positive signal in studiesFelt benefit focusSupplement context
Potential benefit studied in Cognition and focus.
Open metrics
>
Cognition, memory, and focus
No direct rate reported. Read direction and evidence strength together.
Evidence score
51.3
Score reflects signal strength. Tier also considers paper count, repetition, and study context.

Recent research

Updated This Month10 new papers

10 new papers were added in this period. No new risk signal was identified.

What's new

10 new papers were added.No new risk signal was identified.

Most notable recent finding

This is the most meaningful new study in the latest update.
review
Why it mattersIt ranked highest among the newly collected papers for this ingredient in the latest update.
View paper

Study dosage range (reference only)

Lower dose
21
mg/day
Higher dose
1250
mg/day
Dosages used in research papers, shown as reference context.
Not personal dosing instructions, recommendations, or safety limits.

Key cautions to review

Standalone side-effect signals and combination cautions are listed separately.

Caution index
1.6
Caution band: Low
Caution signals
9
Side effects + combos + curated rules
Key precautions
No combination caution signal is clear enough to show right now. This does not guarantee safety.
Standalone side effects, combination cautions, and positive combos are separated below.

Combination caution signals

! BenzodiazepinesGABAergic activity may lead to pharmacodynamic interactions with benzodiazepines.

Standalone side effects

Adverse effect signal1 papers
Two new cases of ashwagandha-induced liver injury were reported, with one case resulting in liver transplantation, and RUCAM scores indicated a probable relationship.human · unknown
Hepatotoxicity1 papers
The review describes cases of suspected ashwagandha-induced liver injury characterized by acute hepatitis, jaundice, and elevated liver enzymes, highlighting its hepatotoxic potential.human · unknown
Hepatotoxicity1 papers
The review reports multiple cases of ashwagandha-induced liver injury, including one requiring transplantation, indicating significant safety concerns.human · systematic-review
Visual hallucination1 papers
A single case report describes visual hallucinations induced by Ashwagandha consumption.human · unknown
Hepatotoxicity1 papers
Several case reports indicate that Ashwagandha intake may induce liver injury in patients using commercial products containing the extract.human · unknown
Adverse effect signal1 papers
Several case reports have reported that taking ashwagandha may induce liver injury in patients using commercial products containing this extract.human · unknown
Adverse effect signal1 papers
Visual hallucination was reported in a patient taking Ashwagandha, described as the first such case in the literature.human · unknown
Adverse effect signal1 papers
Hepatotoxic effects, somnolence, drowsiness, vertigo, decreased appetite, and blurring of vision have been reported with Ashwagandha use.human · unknown

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1
Public scholarly dataCitation signal: 255
review

A narrative review delves into the most recent findings and provides a comprehensive overview of the current understanding of ashwagandha’s potential uses and any known safety concerns and contraindications.

Key Evidence #2
Public scholarly dataCitation signal: 171
observational

These findings suggest that ashwagandha's stress-relieving effects may occur via its moderating effect on the hypothalamus-pituitary-adrenal axis, and further investigation utilizing larger sample sizes, diverse clinical and cultural populations, and varying t

Key Evidence #3
Public scholarly dataCitation signal: 164
observational

It is reported that ashwagandha supplementation is associated with significant increases in muscle mass and strength and suggests that ashWag andha supplementation may be useful in conjunction with a resistance training program.

3 more summariesLimited representative sample by study type.
>
Public scholarly dataCitation signal: 150
observational

This is the first study to offer insight into dose-response of a high concentration root extract and Ashwagandha root aqueous extract was beneficial in reducing stress and anxiety in stressed healthy adults.

Public scholarly dataCitation signal: 135
observational

Ashwagandha (Withania somnifera) (WS), a “rasayana” drug, is recommended for balavardhan and mamsavardh and appeared safe and strengthened muscle activity in normal individuals, in view of its traditional Rasayana use.

Public scholarly dataCitation signal: 119
observational

The study suggests that Withanoside V in Ashwagandha may be serve as a potential inhibitor against Mpro of SARS-CoV-2 to combat COVID-19 and may have an antiviral effect on nCoV.

Ashwagandha
arrow_backBack to list