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arrow_backExplore/Ashwagandha
Tier-BPublic-ready7/5/2026

Ashwagandha

Stress Response and Sleep Changes is the main area connected here, and any felt benefit should be read together with the human evidence base.

Some human supplement-context evidence is present and directly informs the score.

Representative tier calculated from paper evidence that passed the collection audit.

Papers analyzed
116
Caution signal
Low
Representative score
79.0
Stress Response and Sleep ChangesExercise performance and recoveryCognition, memory, and focus

Main benefit evidence

The representative ingredient tier is calculated from these target-level evidence groups.

Stress and mood
8 studiesTier-A
Stress Response and Sleep Changes
Fairly consistent positive signal in studiesFelt benefit focusSupplement context

These findings come from stress response, cortisol, anxiety, or sleep outcomes. They may mix felt benefits with physiological markers.

Evidence score
78.0
Study context
Supplement context

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Exercise performance and recovery
3 studiesTier-B
Exercise performance and recovery
Fairly consistent positive signal in studiesFelt benefit focusSupplement context

Potential benefit studied in Exercise performance and recovery.

Evidence score
66.0
Study context
Supplement context

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Cognition and focus
3 studiesTier-B
Cognition, memory, and focus
Fairly consistent positive signal in studiesFelt benefit focusSupplement context

Potential benefit studied in Cognition and focus.

Evidence score
59.7
Study context
Supplement context

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Glucose and metabolic health
2 studiesTier-B
Glucose and metabolic health markers
Fairly consistent positive signal in studiesResearch marker focusSupplement context

This card is closer to a measured biomarker or lab outcome than a directly felt user benefit.

Evidence score
58.0
Study context
Supplement context

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Men's health
3 studiesTier-B
Male Reproductive Health Markers
Fairly consistent positive signal in studiesResearch marker focusPatient-group study

These findings come from sperm, semen, or hormone markers such as testosterone, LH, FSH, and inhibin B. They are closer to research measurements than a directly felt benefit. These findings come from a defined study population, so everyday effects may differ.

Evidence score
52.0
Study context
Patient-group study

This score reflects the strength of this benefit group. The ingredient tier also considers paper count, repetition, population, and study context.

Recent research

Updated This Month10 new papers

Observed range in repeated studies

This range includes studies in specific patient groups. It is not a general dose or recommendation.

Lower observed study value
21
mg/day
Higher observed study value
1250
mg/day
Only ranges repeated in human, oral, single-ingredient studies are shown.
Not personal dosing instructions, recommendations, or safety limits.

Side effects and combination findings in studies

Findings from studies of this ingredient alone are separated from findings involving another supplement or medication.

Caution index
0.8
Caution band: Low
Caution signals
8
Side effects + combos + curated rules
Key precautions
No curated contraindication rule is available yet, but literature caution signals are shown below.
These are signals reported in studies. They do not predict what will happen to an individual.

Findings to review with care

Side effects reported for the ingredient alone are separated from findings involving another supplement or medication.

Side effects reported when this ingredient was used alone

Symptoms or adverse events reported in studies of this ingredient without another active ingredient.

Hepatotoxicity1 papers
The review identifies Withania somnifera (Ashwagandha) as a commonly used herbal component with inherent hepatotoxicity potential that can lead to acute liver failure.Human studies · Systematic review
Adverse effect signal1 papers
The study reported that 70% ethanol ashwagandha root extracts modulated CYP3A4 enzyme expression and activity in primary human hepatocytes, highlighting potential risks for co-administration with prescribed drugs.Human studies · Study type not identified
Adverse effect signal1 papers
Preliminary studies observed dose- and time-dependent cytotoxic effects on hepatocyte viability at high concentrations of 70% ethanol ashwagandha leaf extracts.Human studies · Study type not identified
Gastrointestinal issues1 papers
Some studies included in the review report gastrointestinal issues associated with Ashwagandha supplementation.Human studies · Systematic review
Adverse effect signal1 papers
The review states that potential interactions with medications are reported, necessitating caution and consultation with healthcare providers.Human studies · Study type not identified
Treatment-emergent adverse events (nausea, abdominal pain, drowsiness)1 papers
Seven participants in the Ashwagandha group reported mild adverse events including nausea, abdominal pain, and drowsiness, which resolved without intervention.Human studies · Randomized controlled trial
Gastrointestinal-related adverse events1 papers
Gastrointestinal-related adverse events were reported in 53 participants in the Withania somnifera arm, described as excellent tolerability overall.Human studies · Randomized controlled trial
Adverse effect signal1 papers
The review mentions that some studies report gastrointestinal issues associated with Ashwagandha supplementation.Human studies · Study type not identified

Evidence summaries

Paper IDs and full lists are private. Only study types and summaries are shown.

Key Evidence #1
Public scholarly dataCitation signal: 261
review

A narrative review delves into the most recent findings and provides a comprehensive overview of the current understanding of ashwagandha’s potential uses and any known safety concerns and contraindications.

Key Evidence #2
Public scholarly dataCitation signal: 231
rct

[Abstract]: Hypoglycemic, diuretic and hypocholesterolemic effects of roots of W. somnifera (ashvagandha) were assessed on human subjects. Six mild NIDDM subjects and six mild hypercholesterolemic subjects were treated with the powder of roots of W. somnifera

Key Evidence #3
Public scholarly dataCitation signal: 199
rct

[Abstract]: Cognitive decline is often associated with the aging process. Ashwagandha (Withania somnifera (L.) Dunal) has long been used in the traditional Ayurvedic system of medicine to enhance memory and improve cognition. This pilot study was designed to e

3 more summariesLimited representative sample by study type.
>
Public scholarly dataCitation signal: 175
rct

[Abstract]: To investigate the impact of Withania somnifera roots on semen profile, oxidative biomarkers, and reproductive hormone levels of infertile men. Prospective study. Departments of Biochemistry and Urology, Chhatrapati Shahuji Maharaj Medical Universi

Public scholarly dataCitation signal: 174
rct

[Abstract]: Abstract Background: Ashwagandha (Withania somnifera (L.) Dunal) is a herb traditionally used to reduce stress and enhance wellbeing. The aim of this study was to investigate its anxiolytic effects on adults with self-reported high stress and to ex

Public scholarly dataCitation signal: 150
review

[Abstract]: Background Withania somnifera (WS), also known as Ashwagandha, is commonly used in Ayurveda and other traditional medicine systems. WS has seen an increase in worldwide usage due to its reputation as an adaptogen. This popularity has elicited incre

Ashwagandha
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