Glucose and metabolic health
Glucose and metabolic health markers
Goal tierBefore the new standard analysis
This ingredient-goal pair has not been processed under the current evidence standard yet.
Check this goal in more detailPublic-ready7/2/2026
Alpha-Lipoic Acid
Papers analyzed
54
Glucose and metabolic health markersBlood pressure and vascular health markersCognition, memory, and focus
Main benefit evidence
Review human evidence by goal.
Blood pressure and vascular health
Blood pressure and vascular health markers
Goal tierNot rated yet
The currently linked research coverage is not broad enough to characterize this goal yet.
Check this goal in more detailCognition and focus
Cognition, memory, and focus
Goal tierBefore the new standard analysis
This ingredient-goal pair has not been processed under the current evidence standard yet.
Check this goal in more detailSide effects and combination findings in studies
Findings from studies of this ingredient alone are separated from findings involving another supplement or medication.
Caution signals
7
Side effects + combos + curated rules
Key precautions
No curated contraindication rule is available yet, but literature caution signals are shown below.
1 combo signals and 0 added-signal combos shown below.
These are signals reported in studies. They do not predict what will happen to an individual.
Findings to review with care
Side effects reported for the ingredient alone are separated from findings involving another supplement or medication.
Side effects reported when this ingredient was used alone
Symptoms or adverse events reported in studies of this ingredient without another active ingredient.
Adverse effect signal1 papers
A case report described potentially life-threatening relapsing hypoglycaemia due to insulin autoimmune syndrome precipitated by alpha-lipoic acid in a patient with monoclonal gammopathy of undetermined significance.Human studies · Study type not identifiedAdverse effect signal1 papers
A case was reported where alpha-lipoic acid supplementation induced insulin autoimmune antibody syndrome, resulting in severe hypoglycemia and unresponsiveness in a non-diabetic female.Human studies · Study type not identifiedAdverse effect signal1 papers
The study reports a case where alpha-lipoic acid exposure was linked to the development of insulin autoimmune syndrome (IAS), characterized by hypoglycemia and high insulin autoantibody titers.Human studies · Study type not identifiedAdverse effect signal1 papers
A case report described severe recurrent hypoglycaemia associated with high insulin and C-peptide levels in a patient who consumed alpha-lipoic acid, leading to a diagnosis of insulin autoimmune syndrome (IAS).Human studies · Study type not identifiedAdverse effect signal1 papers
A case report described a potential relationship between alpha-lipoic acid consumption and the development of insulin autoimmune syndrome (IAS) in a patient presenting with recurrent hypoglycemia.Human studies · Study type not identifiedAdverse effect signal1 papers
Anti-insulin antibody syndrome, characterized by severe hypoglycemia and elevated insulin autoantibodies, was reported in three human cases following alpha-lipoic acid use.Human studies · Study type not identifiedAdverse effect signal1 papers
Alpha-lipoic acid was reported to induce or exacerbate hypoglycemia in a patient with Insulin Autoimmune Syndrome (IAS), leading to a diagnosis of hyperinsulinemic hypoglycemia.Human studies · Study type not identifiedPositive combinations studied
Positive combination findings are separated by how the study compared the groups. This is not a recommendation to combine them.
Positive findings when used together
The combination had a positive result, but the contribution of each ingredient could not be separated.
오메가-3The combination of omega-3 fatty acids and alpha-lipoic acid showed significant benefits in slowing cognitive and functional decline compared to placebo or omega-3 alone.
Alpha-Lipoic Acid
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